2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation.

ID: ALA1153992

Journal: Bioorg Med Chem Lett

Title: 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation.

Authors: Weterings JJ, Khan S, van der Heden van Noort GJ, Melief CJ, Overkleeft HS, van der Burg SH, Ossendorp F, van der Marel GA, Filippov DV.

Abstract: The synthesis of an array of 2-azidoalkoxy substituted 7-hydro-8-oxoadenines is described. The relation of the structure of these compounds and their ability to induce maturation of dendritic cells is evaluated.

CiteXplore: 19299126

DOI: 10.1016/j.bmcl.2009.02.095

Patent ID: ┄