Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives.
Basic Information
ID: ALA1154071
Journal: Eur J Med Chem
Title: Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives.
Authors: Kümmerle AE, Raimundo JM, Leal CM, da Silva GS, Balliano TL, Pereira MA, de Simone CA, Sudo RT, Zapata-Sudo G, Fraga CA, Barreiro EJ.
Abstract: In this report we disclose the synthesis, vasodilatory activity, and identification of bioactive conformation of new N-acylhydrazone and N-methyl-N-acylhydrazone derivatives, structurally designed by bioisosteric replacements of previously described cardioactive compounds LASSBio-294 and its N-methyl derivative LASSBio-785. Some of these novel derivatives presented improved vasorelaxant properties, being new cardiovascular drug candidates.
CiteXplore: 19500884
DOI: 10.1016/j.ejmech.2009.04.044
Patent ID: ┄