Scalarane sesterterpenes from the sponge Smenospongia sp.
Basic Information
ID: ALA1154134
Journal: J Nat Prod
Title: Scalarane sesterterpenes from the sponge Smenospongia sp.
Authors: Song J, Jeong W, Wang N, Lee HS, Sim CJ, Oh KB, Shin J.
Abstract: Ten new sesterterpene compounds (4-13) and seven known metabolites (1-3, 14-17) were isolated from the sponge Smenospongia sp. collected from Korean coastal waters. On the basis of combined spectroscopic analyses, the new compounds exhibited diverse functionalities on a common scalarane sesterterpene structure. The presence of a 23-aldehyde on compound 6 and a 20-carboxylic acid on 11 is unprecedented among sponge-derived scalarane sesterterpenes. Several of the new compounds showed significant cytotoxicity and antimicrobial activity, as well as moderate inhibitory activity against isocitrate lyase.
CiteXplore: 18973387
DOI: 10.1021/np8003694
Patent ID: ┄