Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation.

ID: ALA1154152

Journal: Eur J Med Chem

Title: Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation.

Authors: Venkat Ragavan R, Vijayakumar V, Suchetha Kumari N.

Abstract: alpha-Oxy/thio substituted-beta-keto esters were synthesized through an efficient cross-Claisen condensation of aryl oxy/thio acetic acid ethyl esters with acid chlorides, then it is converted in situ into 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones by the addition of hydrazine or hydrazine derivatives and screened for their antibacterial, antifungal activities.

CiteXplore: 19423195

DOI: 10.1016/j.ejmech.2009.04.010

Patent ID: ┄