Document Report Card

ID: ALA1154283

Journal: J Nat Prod

Title: Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum.

Authors: Ismail IS, Nagakura Y, Hirasawa Y, Hosoya T, Lazim MI, Lajis NH, Shiro M, Morita H.

Abstract: Four new chromone alkaloids, chrotacumines A-D (1-4), consisting of a 5,7-dihydroxy-2-methylchromone, an N-Me piperidine ring, and an ester side chain were isolated from Dysoxylum acutangulum, and their structures including absolute configurations were elucidated on the basis of spectroscopic data interpretation including 2D NMR, CD spectra, and X-ray analysis. The known compound rohitukine (5) showed moderate cytotoxicity against human HL-60 promyelocytic leukemia and HCT-116 colon cancer cells.

CiteXplore: 19757855

DOI: 10.1021/np9003849