Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists.

ID: ALA1154292

Journal: Bioorg Med Chem Lett

Title: Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists.

Authors: Pasternak A, Goble SD, deJesus RK, Hreniuk DL, Chung CC, Tota MR, Mazur P, Feighner SD, Howard AD, Mills SG, Yang L.

Abstract: This Letter describes optimization of ghrelin receptor antagonists and inverse agonists starting from a screening hit.

CiteXplore: 19767208

DOI: 10.1016/j.bmcl.2009.08.076

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