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ID: ALA1154390
Journal: Bioorg Med Chem Lett
Title: Synthesis and PKCtheta inhibitory activity of a series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles.
Authors: Shim J, Eid C, Lee J, Liu E, Chaudhary D, Boschelli DH.
Abstract: A series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles were prepared and evaluated as PKCtheta inhibitors. Optimization resulted in the identification of compound 15 with an IC(50) value 0.44 nM for the inhibition of PKCtheta with 150-fold selectivity over PKCdelta.
CiteXplore: 19854645