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ID: ALA1154392
Journal: Bioorg Med Chem Lett
Title: Discovery of highly potent and selective type I B-Raf kinase inhibitors.
Authors: Wang X, Berger DM, Salaski EJ, Torres N, Hu Y, Levin JI, Powell D, Wojciechowicz D, Collins K, Frommer E.
Abstract: A series of pyrazolo[1,5-alpha]pyrimidine analogs has been prepared and found to be potent and selective B-Raf inhibitors. Molecular modeling suggests they bind to the active conformation of the enzyme.
CiteXplore: 19854649