Document Report Card

ID: ALA1154411

Journal: Antimicrob Agents Chemother

Title: Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action.

Authors: Pfeiffer ES, Hiasa H.

Abstract: We used an assay to measure quinolone sensitivity as a shift in the position of the cleavage-religation equilibrium. This assay was found to be useful in identifying the primary target of a quinolone drug and assessing the effect of quinolone resistance-conferring mutations.

CiteXplore: 17606687

DOI: 10.1128/aac.00362-07