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ID: ALA1154450

Journal: Eur J Med Chem

Title: Synthesis and biological evaluation of diversely substituted indolin-2-ones.

Authors: Bouchikhi F, Rossignol E, Sancelme M, Aboab B, Anizon F, Fabbro D, Prudhomme M, Moreau P.

Abstract: The synthesis of indolin-2-one derivatives substituted in the 3-position by an aminomethylene group bearing either an ornithine or a lysine residue is described. The inhibitory activities of these compounds toward a panel of eight kinases were examined. Furthermore, the antibacterial activities of the prepared compounds were tested against two Gram-positive bacteria Bacillus cereus and Streptomyces chartreusis, a Gram-negative bacterium Escherichia coli and a yeast Candida albicans.

CiteXplore: 18313174

DOI: 10.1016/j.ejmech.2008.01.010