Cytotoxic biflavonoids from Selaginella delicatula.
Basic Information
ID: ALA1154577
Journal: J Nat Prod
Title: Cytotoxic biflavonoids from Selaginella delicatula.
Authors: Lin LC, Kuo YC, Chou CJ.
Abstract: Four new biflavonoids-robustaflavone 4'-methyl ether (1), robustaflavone 7,4'-dimethyl ether (2), 2",3" -dihydrorobustaflavone 7,4', -dimethyl ether (3), and 2",3" '-dihydrorobustaflavone 7,4', 7"-trimethyl ether (4)-as well as two known biflavonoids, robustaflavone and amentoflavone, and three caffeoylquinic acids, 3,5-di-O-caffeoylquinic acid, 3, 4-di-O-caffeoylquinic acid, and 4,5-di-O-caffeoylquinic acid, were isolated from Selaginella delicatula. The structures of the new compounds were established by spectroscopic analysis and chemical modification. The cytotoxic activity of these compounds on various tumor cell lines was evaluated, and both compounds 1 and 3 significantly suppressed the growth of Raji and Calu-1 tumor cell lines.
CiteXplore: 10843573
DOI: 10.1021/np990538m
Patent ID: ┄