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ID: ALA1154587
Journal: Bioorg Med Chem Lett
Title: Discovery of novel sphingosine kinase 1 inhibitors.
Authors: Xiang Y, Asmussen G, Booker M, Hirth B, Kane JL, Liao J, Noson KD, Yee C.
Abstract: Sphingosine kinase 1 (SK1) is an important enzyme that regulates the balance between ceramide and sphingosine-1-phosphate (S1P). Potent and novel SK1 inhibitors (6ag, 9ab and 12aa) have been discovered through a series of modifications of sphingosine (1), the substrate of this enzyme.
CiteXplore: 19800228