Document Report Card

ID: ALA1154602

Journal: J Med Chem

Title: Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.

Authors: Bolognesi ML, Cavalli A, Bergamini C, Fato R, Lenaz G, Rosini M, Bartolini M, Andrisano V, Melchiorre C.

Abstract: Novel multitargeted antioxidants 3-6 were designed by combining the antioxidant features, namely, a benzoquinone fragment and a lipoyl function, of two multifunctional lead candidates. They were then evaluated to determine their profile against Alzheimer's disease. They showed antioxidant activity, improved following enzymatic reduction, in mitochondria and T67 cell line. They also displayed a balanced inhibitory profile against amyloid-beta aggregation and acetylcholinesterase, emerging as promising molecules for neuroprotectant lead discovery.

CiteXplore: 19813747

DOI: 10.1021/jm901123n