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ID: ALA1154701
Journal: Eur J Med Chem
Title: Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH).
Authors: Becker A, Kohfeld S, Lader A, Preu L, Pies T, Wieking K, Ferandin Y, Knockaert M, Meijer L, Kunick C.
Abstract: A collection of paullones was tested for inhibitory activity against mitochondrial malate dehydrogenase (mMDH) as a biological target for antiproliferative activity. Based on the results of this screening, 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters were developed as selective mMDH inhibitors. The new derivatives did not show noteworthy antiproliferative activity when tested on a panel of cancer cell lines, suggesting that mMDH inhibition is of minor relevance for the growth inhibition caused by paullones.
CiteXplore: 19906467