Document Report Card

ID: ALA1154754

Journal: J Med Chem

Title: Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole.

Authors: Wang T, Duffy JP, Wang J, Halas S, Salituro FG, Pierce AC, Zuccola HJ, Black JR, Hogan JK, Jepson S, Shlyakter D, Mahajan S, Gu Y, Hoock T, Wood M, Furey BF, Frantz JD, Dauffenbach LM, Germann UA, Fan B, Namchuk M, Bennani YL, Ledeboer MW.

Abstract: The synthesis and characterization of a novel polycyclic azaindole based derivative is disclosed, and its binding to JAK2 is described. The compound is further evaluated for its ability to block the EPO/JAK2 signaling cascade in vitro and in vivo.

CiteXplore: 20014869

DOI: 10.1021/jm901383u