Document Report Card

ID: ALA1154780

Journal: J Med Chem

Title: Synthesis of new linear guanidines and macrocyclic amidinourea derivatives endowed with high antifungal activity against Candida spp. and Aspergillus spp.

Authors: Manetti F, Castagnolo D, Raffi F, Zizzari AT, Rajamäki S, D'Arezzo S, Visca P, Cona A, Fracasso ME, Doria D, Posteraro B, Sanguinetti M, Fadda G, Botta M.

Abstract: New linear and cyclic guanidines were synthesized and tested in vitro for their antifungal activity toward clinically relevant strains of Candida species, in comparison to fluconazole. Macrocyclic compounds showed a minimum inhibitory concentration in the micromolar range and a biological activity profile in some cases better than that of fluconazole. One macrocyclic derivative was also tested against Aspergillus species and showed high antifungal activity comparable to that of amphotericin B and itraconazole.

CiteXplore: 19650630

DOI: 10.1021/jm900760k