Document Report Card

ID: ALA1154880

Journal: J Nat Prod

Title: Hydroxylated sclerosporin derivatives from the marine-derived fungus Cadophora malorum.

Authors: Almeida C, Eguereva E, Kehraus S, Siering C, König GM.

Abstract: The marine-derived fungus Cadophora malorum was isolated from the green alga Enteromorpha sp. Growth on a biomalt medium supplemented with sea salt yielded an extract, from which we have isolated sclerosporin and four new hydroxylated sclerosporin derivatives, namely, 15-hydroxysclerosporin (2), 12-hydroxysclerosporin (3), 11-hydroxysclerosporin (4), and 8-hydroxysclerosporin (5). The compounds were evaluated in various biological activity assays. Compound 5 showed a weak fat-accumulation inhibitory activity against 3T3-L1 murine adipocytes.

CiteXplore: 20052971

DOI: 10.1021/np900608d