Novel tetrahydrochinoline derived CETP inhibitors.

Basic Information

ID: ALA1154929

Journal: Bioorg Med Chem Lett

Title: Novel tetrahydrochinoline derived CETP inhibitors.

Authors: Schmeck C, Gielen-Haertwig H, Vakalopoulos A, Bischoff H, Li V, Wirtz G, Weber O.

Abstract: In the course of our efforts to identify orally active cholesteryl ester transfer protein (CETP) inhibitors, we have continued to explore tetrahydrochinoline derivatives. Based on BAY 19-4789 structural modifications led to the discovery of novel cycloalkyl substituted compounds. Thus, example 11b is a highly potent CETP inhibitor both in vitro and in vivo in transgenic mice with favourable pharmacokinetic properties for clinical development.

CiteXplore: 20137927

DOI: 10.1016/j.bmcl.2010.01.071

Patent ID: ┄