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ID: ALA1154968
Journal: Bioorg Med Chem Lett
Title: Tellimagrandin I, HCV invasion inhibitor from Rosae Rugosae Flos.
Authors: Tamura S, Yang GM, Yasueda N, Matsuura Y, Komoda Y, Murakami N.
Abstract: By use of the model virus, expressing the HCV envelope proteins E1 and E2, bioassay guided separation of the MeOH extract from Rosa rugosa Thunb. disclosed tellimagrandin I (1) together with eugeniin (2) and casuarictin (3) as the potent HCV invasion inhibitors. Furthermore, structure-activity relationship analysis of some relative tannins including the synthesized analogs elucidated the partial structures crucial for potent activity of 1.
CiteXplore: 20144544