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ID: ALA1155016

Journal: Bioorg Med Chem

Title: Locking the two ends of tetrapeptidic HTLV-I protease inhibitors inside the enzyme.

Authors: Zhang M, Nguyen JT, Kumada HO, Kimura T, Cheng M, Hayashi Y, Kiso Y.

Abstract: Adult T-cell leukemia and tropical spastic paraparesis/HTLV-I-associated myelopathy are only some of the more common end results of an infection with a human T-cell leukemia virus type 1 (HTLV-I). Expanding from our previous reports, we synthesized all different permutations of tetrapeptidic HTLV-I protease inhibitors using at least eight P(3)-cap and five P(1)(')-cap moieties. The inhibitors exhibited over 97% inhibition against HIV-1 protease and a wide range of inhibitory activity against HTLV-I protease.

CiteXplore: 18558491

DOI: 10.1016/j.bmc.2008.05.052