Document Report Card

ID: ALA1155134

Journal: J Med Chem

Title: Structural basis for the potent calpain inhibitory activity of peptidyl alpha-ketoacids.

Authors: Donkor IO, Assefa H, Liu J.

Abstract: A series of peptidyl alpha-ketoacids and alpha-ketoesters was synthesized and studied as mu-calpain inhibitors. Docking studies revealed that the mu-calpain inhibitory activity of the compounds is influenced by hydrogen bonding interactions and the potential for ionic interaction with active site residues as well as placement of a planar N-terminal capping group into the S 3 pocket of the enzyme.

CiteXplore: 18636690

DOI: 10.1021/jm800182c