Amplification of the inhibitory activity of miglitol by monofluorination.

ID: ALA1155187

Journal: Bioorg Med Chem Lett

Title: Amplification of the inhibitory activity of miglitol by monofluorination.

Authors: Prell E, Csuk R.

Abstract: Selective monofluorination of the alpha-glycosidase inhibitor and antidiabetic agent Miglitol at position C2 creates an competitive inhibitor of five times higher activity than the parent compound. Its screening against a panel of human cell lines showed a low cytotoxicity therefore making this compound an interesting candidate for further clinical investigations.

CiteXplore: 19700320

DOI: 10.1016/j.bmcl.2009.08.012

Patent ID: ┄