Antinociceptive properties of caffeic acid derivatives in mice.
Basic Information
ID: ALA1155293
Journal: Eur J Med Chem
Title: Antinociceptive properties of caffeic acid derivatives in mice.
Authors: de Campos Buzzi F, Franzoi CL, Antonini G, Fracasso M, Cechinel Filho V, Yunes RA, Niero R.
Abstract: Ten ester derivatives from caffeic acid were synthesized, and their antinociceptive properties are evaluated in mice. The most active compound, dodecyl ester derivative, exhibited potent and dose-related activity against the writhing test, with a calculated ID(50) value of 15.1 (11.9-19.1)micromol/kg and MI of 78.8% being several times more active than reference drugs. It was also effective in other experimental models, such as formalin, capsaicin and glutamate-induced pain tests, but was inactive in the hot-plate test. Although the mechanism of action has still not been elucidated, these results appear to support its therapeutic potential against painful diseases.
CiteXplore: 19628311
DOI: 10.1016/j.ejmech.2009.06.029
Patent ID: ┄