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ID: ALA1155308
Journal: Bioorg Med Chem Lett
Title: Metallo-beta-lactamase inhibitory activity of phthalic acid derivatives.
Authors: Hiraiwa Y, Morinaka A, Fukushima T, Kudo T.
Abstract: 4-Butyl-3-methylphthalic acid was recognized as a metallo-beta-lactamase inhibitor. The structure-activity relationship study of substituted phthalic acids afforded 3-phenylphthalic acid derivatives as potent IMP-1 inhibitors. On the other hand, 3-substituted with 4-hydroxyphenyl phthalic acid derivative displayed a potent combination effect with biapenem (BIPM) against Pseudomonas aeruginosa that produce IMP-1.
CiteXplore: 19632114