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ID: ALA1155393
Journal: Bioorg Med Chem Lett
Title: Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.
Authors: Lesuisse D, Dutruc-Rosset G, Tiraboschi G, Dreyer MK, Maignan S, Chevalier A, Halley F, Bertrand P, Burgevin MC, Quarteronet D, Rooney T.
Abstract: From an HTS hit, a series of potent and selective inhibitors of GSK3beta have been designed based on a Cdk2-homology model and with the help of several crystal structures of the compounds within Cdk2.
CiteXplore: 20167481