Structure-activity relationship for thiohydantoin androgen receptor antagonists for castration-resistant prostate cancer (CRPC).

ID: ALA1155462

Journal: J Med Chem

Title: Structure-activity relationship for thiohydantoin androgen receptor antagonists for castration-resistant prostate cancer (CRPC).

Authors: Jung ME, Ouk S, Yoo D, Sawyers CL, Chen C, Tran C, Wongvipat J.

Abstract: A structure-activity relationship study was carried out on a series of thiohydantoins and their analogues 14 which led to the discovery of 92 (MDV3100) as the clinical candidate for the treatment of hormone refractory prostate cancer.

CiteXplore: 20218717

DOI: 10.1021/jm901488g

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