A vHTS approach for the identification of beta-adrenoceptor ligands.

Basic Information

ID: ALA1155476

Journal: Bioorg Med Chem Lett

Title: A vHTS approach for the identification of beta-adrenoceptor ligands.

Authors: Tasler S, Baumgartner R, Aschenbrenner A, Ammendola A, Wolf K, Wieber T, Schachtner J, Blisse M, Quotschalla U, Ney P.

Abstract: Using a vHTS based on a pharmacophore alignment on known beta3-adrenoceptor ligands, a set of intriguing beta-adrenoceptor ligands was identified, optimization of which resulted in a selective and potent human beta2-AR antagonist.

CiteXplore: 20434333

DOI: 10.1016/j.bmcl.2010.04.009

Patent ID: ┄

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