Document Report Card

ID: ALA1155596

Journal: J Nat Prod

Title: 8-O-Methylsclerotiorinamine, antagonist of the Grb2-SH2 domain, isolated from Penicillium multicolor.

Authors: Nam JY, Kim HK, Kwon JY, Han MY, Son KH, Lee UC, Choi JD, Kwon BM.

Abstract: A new secondary metabolite, 8-O-methylsclerotiorinamine (1), was isolated from a strain of Penicillium multicolor, and its structure was established using NMR spectroscopy and chemical evidence. The metabolite inhibited significantly the binding between the Grb2-SH2 domain and the phosphopeptide derived from the Shc protein and also blocked the protein-protein interactions of Grb2-Shc in cell-based experiments, with IC(50) values of 5.3 and 50 microM, respectively.

CiteXplore: 11000046

DOI: 10.1021/np0001169