Document Report Card

ID: ALA1155600

Journal: J Nat Prod

Title: Constituents of Boronia pinnata.

Authors: Ito C, Itoigawa M, Otsuka T, Tokuda H, Nishino H, Furukawa H.

Abstract: A novel quinolone, pinolinone (1); seven new phenylpropanoids, boropinols A (2), B (3), C (4), boropinals A (5), B (6), C (7), and boropinic acid (8); and a new lignan, boropinan (9), were isolated from the roots of Boronia pinnata, and their structures were elucidated by NMR and MS analyses. In a search for novel cancer chemopreventive agents (antitumor-promoters), we screened 10 compounds isolated from the plant for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. Boropinic acid (8) and 4'-hydroxy-3'-prenylcinnamaldehyde were observed to significantly inhibit the EBV-EA activation.

CiteXplore: 11076549

DOI: 10.1021/np0000318