Basic Information
ID: ALA1155615
Journal: J Nat Prod
Title: Bioactive saponins from Swartzia schomburgkii from the suriname rainforest.
Authors: Abdel-Kader MS, Bahler BD, Malone S, Werkhoven MC, Wisse JH, Neddermann KM, Bursuker I, Kingston DG.
Abstract: Bioassay-guided fractionation of the MeOH extract of Swartzia schomburgkii using the engineered yeast strains 1138, 1140, and 1353 as the bioassay tool resulted in the isolation of five active (2, 4-7) and three inactive (1, 3, 8) saponins. Saponins 4 and 6 are previously unreported. The structures of all of the saponins were established based on 1D and 2D NMR spectral analysis, on acid and alkaline hydrolysis followed by TLC and GC-MS, and by comparison with literature data for known compounds. Three of the isolated compounds (4-6) showed weak cytotoxicity against the M-109 cell line.
CiteXplore: 11087583
DOI: 10.1021/np0000926
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets