Document Report Card

ID: ALA1155661

Journal: J Nat Prod

Title: Bioactive steroids from the whole herb of Euphorbia chamaesyce.

Authors: Tanaka R, Kasubuchi K, Kita S, Tokuda H, Nishino H, Matsunaga S.

Abstract: Three new ergostane-type steroids, 3beta-hydroxy-4alpha, 14alpha-dimethyl-5alpha-ergosta-8,24(28)-dien-11 -one (1); 3beta, 11alpha-dihydroxy-4alpha,14alpha-dimethyl-5alpha -ergosta-8, 24(28)-dien-7-one (2); and 3beta,7alpha-dihydroxy-4alpha, 14alpha-dimethyl-5alpha-ergosta-8,24(28)-dien-11 -one (3), were isolated, together with two known triterpenoids, wrightial and lup-20(30)-ene-3beta,29-diol from the whole herb of Euphorbia chamaesyce. Compound 3 showed a potent inhibitory effect on Epstein-Barr virus early antigen activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA).

CiteXplore: 10650087

DOI: 10.1021/np990394b