Document Report Card

ID: ALA1155699

Journal: J Nat Prod

Title: Steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin.

Authors: Kalauni SK, Choudhary MI, Shaheen F, Manandhar MD, Atta-ur-Rahman, Gewali MB, Khalid A.

Abstract: Two new steroidal alkaloids, (-)-vaganine D (1) [(20S)-20-(N,N-dimethylamino)-3 beta-(senecioylamino)-5 alpha-pregn-16-en-4 beta-yl acetate], and (+)-nepapakistamine A (2) [(20S)-20-(N-methylamino)-3 beta-(tigloylamino)-5 alpha-pregn-16-en-2 beta,4 beta-diacetate], were isolated from the leaves of Sarcococca coriacea. Their structures were elucidated on the basis of their spectral properties. Compounds 1 and 2 were found to be cholinesterase inhibitors.

CiteXplore: 11421762

DOI: 10.1021/np000466v