Document Report Card

ID: ALA1155708

Journal: J Nat Prod

Title: Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba.

Authors: Suzuki K, Yahara S, Maehata K, Uyeda M.

Abstract: A novel inhibitor of topoisomerase I designated as isoaurostatin (1) was isolated from the culture filtrate of Thermomonospora alba strain No. 1520. The structure of 1 was determined to be 6,4'-dihydroxyisoaurone on the basis of spectroscopic (NMR and MS) methods. Compound 1 inhibited the relaxation activity of calf thymus topoisomerase I in a noncompetitive manner and did not inhibit the relaxation and decatenation of human placenta topoisomerase II. Compound 1 is an inhibitor belonging to cleavable complex-nonforming type without DNA intercalation.

CiteXplore: 11430001

DOI: 10.1021/np0004606