Cytotoxic diacetylenes from the stony coral Montipora species.

ID: ALA1155747

Journal: J Nat Prod

Title: Cytotoxic diacetylenes from the stony coral Montipora species.

Authors: Alam N, Bae BH, Hong J, Lee CO, Im KS, Jung JH.

Abstract: Ten new (1, 4-6, 9-14) and four known (2, 3, 7, 8) diacetylenes have been isolated from a brine shrimp active fraction of the methanolic extract of the stony coral Montipora sp. The structures were determined by combined spectroscopic methods. The compounds exhibited significant cytotoxicity against a small panel of human solid tumor cell lines. Montiporyne A (15), a previously reported congener, was also found to induce apoptosis in human colon tumor cell.

CiteXplore: 11520227

DOI: 10.1021/np010148b

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