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ID: ALA1155856

Journal: Bioorg Med Chem Lett

Title: Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines.

Authors: Venu TD, Khanum SA, Firdouse A, Manuprasad BK, Shashikanth S, Mohamed R, Vishwanth BS.

Abstract: Reaction of 6a-f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a-f in excellent yield. The newly synthesized heterocycles were characterized by IR, (1)H NMR, and mass spectral data. Compounds 7a-f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound 7e showed more potent activity than the standard drugs at all doses tested.

CiteXplore: 18621525

DOI: 10.1016/j.bmcl.2008.06.061