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ID: ALA1155891
Journal: Bioorg Med Chem
Title: Synthesis and antiviral evaluation of some new pyrazole and fused pyrazolopyrimidine derivatives.
Authors: Rashad AE, Hegab MI, Abdel-Megeid RE, Micky JA, Abdel-Megeid FM.
Abstract: Some novel substituted pyrazole and pyrazolo[3,4-d]pyrimidine derivatives 2, 4, 8, and 9 were synthesized. Also, some acyclic S-nucleosides of pyrazolo[3,4-d]pyrimidine derivatives 10-13 were prepared via reaction of pyrazolo[3,4-d]pyrimidine-4(3H)-thione derivative 9 with some acyclic sugars. Moreover, the N-nucleoside derivative 14 was prepared via reaction of compound 8 with glucosamine hydrochloride. The antiviral evaluation of some selected new products showed that they have promising antiviral activity against hepatitis-A virus (HAV) and herpes simplex virus type-1 (HSV-1).
CiteXplore: 18635363