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ID: ALA1155900
Journal: Bioorg Med Chem Lett
Title: Design and optimization of potent, selective antagonists of Oxytocin.
Authors: Brown A, Brown L, Ellis D, Puhalo N, Smith CR, Wallace O, Watson L.
Abstract: A novel series of Oxytocin antagonists are described. This series was identified through pharmacophoric overlap of in-house and literature antagonists. Subsequent optimization led to a series of potent, selective antagonists. Several analogues displayed oral bioavailability in vivo in the rat.
CiteXplore: 18639455