Basic Information
ID: ALA1155963
Journal: Bioorg Med Chem Lett
Title: Solubilized phenyl-pyrazole ureas as potent, selective 5-HT(2A) inverse-agonists and their application as antiplatelet agents.
Authors: Dosa PI, Strah-Pleynet S, Jayakumar H, Casper M, Decaire M, Xiong Y, Lehmann J, Choi K, Elwell K, Wong A, Webb RR, Adams JW, Ramirez J, Richman JG, Thomsen W, Semple G, Teegarden BR.
Abstract: Potent 5-HT(2A) inverse-agonists containing phenyl-pyrazole ureas with an amino side chain were identified. Optimization of this series resulted in selective compounds that proved effective in modulating 5HT-induced amplification of ADP-stimulated human platelet aggregation.
CiteXplore: 19665894
DOI: 10.1016/j.bmcl.2009.07.073
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets