Addressing the malaria drug resistance challenge using flow cytometry to discover new antimalarials.

ID: ALA1155965

Journal: Bioorg Med Chem Lett

Title: Addressing the malaria drug resistance challenge using flow cytometry to discover new antimalarials.

Authors: Grimberg BT, Jaworska MM, Hough LB, Zimmerman PA, Phillips JG.

Abstract: A new flow cytometry method that uses an optimized DNA and RNA staining strategy to monitor the growth and development of the Plasmodium falciparum strain W2mef has been used in a pilot study and has identified Bay 43-9006 1, SU 11274 2, and TMC 125 5 as compounds that exhibit potent (<1 microM) overall and ring stage in vitro antimalarial activity.

CiteXplore: 19666223

DOI: 10.1016/j.bmcl.2009.07.095

Patent ID: ┄