Document Report Card
Basic Information
ID: ALA1156062
Journal: Bioorg Med Chem Lett
Title: Synthesis, SAR, and X-ray structure of tricyclic compounds as potent FBPase inhibitors.
Authors: Tsukada T, Takahashi M, Takemoto T, Kanno O, Yamane T, Kawamura S, Nishi T.
Abstract: With the aim of discovering a novel class of fructose-1,6-bisphosphatase (FBPase) inhibitors, a series of compounds based on tricyclic scaffolds was synthesized. Extensive SAR studies led to the finding of 8l with an IC50 value of 0.013 microM against human FBPase. An X-ray crystallographic study revealed that 8l bound at AMP binding sites of human liver FBPase with hydrogen bonding interactions similar to AMP.
CiteXplore: 19762234