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ID: ALA1156111
Journal: Bioorg Med Chem Lett
Title: Identification of the amino acid-AZT-phosphoramidase by affinity T7 phage display selection.
Authors: Cheng J, Zhou X, Chou TF, Ghosh B, Liu B, Wagner CR.
Abstract: A CEM cell cDNA T7 phage display library was prepared and used to screen for activating enzymes of phosphoramidate prodrugs of AZT monophosphate. Although, inefficient compared to ribonucleotide based phosphoramidates, hHint 1 was identified as the likely intracellular pronucleotide activating enzyme.
CiteXplore: 19825512