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ID: ALA1156111

Journal: Bioorg Med Chem Lett

Title: Identification of the amino acid-AZT-phosphoramidase by affinity T7 phage display selection.

Authors: Cheng J, Zhou X, Chou TF, Ghosh B, Liu B, Wagner CR.

Abstract: A CEM cell cDNA T7 phage display library was prepared and used to screen for activating enzymes of phosphoramidate prodrugs of AZT monophosphate. Although, inefficient compared to ribonucleotide based phosphoramidates, hHint 1 was identified as the likely intracellular pronucleotide activating enzyme.

CiteXplore: 19825512

DOI: 10.1016/j.bmcl.2009.09.067