Document Report Card
Basic Information
ID: ALA1156162
Journal: Bioorg Med Chem
Title: Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones.
Authors: Mrozek-Wilczkiewicz A, Kalinowski DS, Musiol R, Finster J, Szurko A, Serafin K, Knas M, Kamalapuram SK, Kovacevic Z, Jampilek J, Ratuszna A, Rzeszowska-Wolny J, Richardson DR, Polanski J.
Abstract: A group of styrylazanaphthalenes and azanaphthalenediones were synthesized and tested for their anti-proliferative activity. Most of the compounds were obtained with the use of microwave-assisted synthesis. The lipophilicity of the compounds was measured by RP-HPLC and their anti-proliferative activity was assayed against the human SK-N-MC neuroepithelioma and HCT116 human colon carcinoma cell lines. Active compounds were also tested in clonogenity and comet assays. Several quinazolinone and styrylquinazoline analogues were found to have markedly greater anti-proliferative activity than desferoxamine and cis-platin.
CiteXplore: 20303768