Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3.
Basic Information
ID: ALA1156212
Journal: Bioorg Med Chem Lett
Title: Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3.
Authors: Hu GX, Liang G, Chu Y, Li X, Lian QQ, Lin H, He Y, Huang Y, Hardy DO, Ge RS.
Abstract: Non-steroidal compounds that inhibit 17beta-hydroxysteroid dehydrogenase isoform 3 (17beta-HSD3), an enzyme catalyzing the final step in testosterone biosynthesis in Leydig cells, are under development for male contraceptive or treatment of androgen dependent diseases including prostate cancer. A series of curcumin analogues with more stable chemical structures were compared to curcumin as inhibitors of 17beta-HSD3 in rat intact Leydig cells as well as rat and human testis microsomes.
CiteXplore: 20346654
DOI: 10.1016/j.bmcl.2010.02.089
Patent ID: ┄