Potent and selective inhibition of human cytochrome P450 3A4 by seco-pancratistatin structural analogs.

ID: ALA1156289

Journal: Bioorg Med Chem Lett

Title: Potent and selective inhibition of human cytochrome P450 3A4 by seco-pancratistatin structural analogs.

Authors: McNulty J, Nair JJ, Singh M, Crankshaw DJ, Holloway AC.

Abstract: seco-Derivatives of the anticancer agent pancratistatin bearing the 2S,3S,4S,5S configuration were accessed via a novel, highly diastereoselective anti-aldol reaction. Structure-activity relationships reveal important insights into the seco-pancratistatin pharmacophore as a potent and selective inhibitor of human cytochrome P450 3A4 (CYP3A4), and highlight features of concern in advancing a potent, selective anticancer agent in the pancratistatin series.

CiteXplore: 20189386

DOI: 10.1016/j.bmcl.2010.01.157

Patent ID: ┄