Identification of amide bioisosteres of triazole oxytocin antagonists.
Basic Information
ID: ALA1156290
Journal: Bioorg Med Chem Lett
Title: Identification of amide bioisosteres of triazole oxytocin antagonists.
Authors: Brown A, Ellis D, Wallace O, Ralph M.
Abstract: A series of amides were investigated as potential bioisosteres of previously reported triazole oxytocin antagonists. A range of potent analogues were identified, although SAR for potency and selectivity over the related V(1A) and V(2) receptors was found to be somewhat divergent from that observed for the corresponding triazole series. The high synthetic accessibility of this new amide series also facilitated the identification of a range of alternative left hand side (biaryl replacement) substituents which gave good levels of oxytocin antagonism.
CiteXplore: 20189387
DOI: 10.1016/j.bmcl.2010.02.018
Patent ID: ┄