Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance.
Basic Information
ID: ALA1156316
Journal: Bioorg Med Chem Lett
Title: Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance.
Authors: Swasono RT, Mouri R, Morsy N, Matsumori N, Oishi T, Murata M.
Abstract: The affinity of amphidinol 3 (AM3) to phospholipid membranes in the presence and absence of sterol was examined by surface plasmon resonance (SPR) experiments. The results showed that AM3 has 1000 and 5300 times higher affinity for cholesterol- and ergosterol-containing liposomes, respectively, than those without sterol. The two-state reaction model well reproduced the sensor grams, which indicated that the interaction is composed of two steps, which correspond to binding to the membrane and internalization to form stable complexes.
CiteXplore: 20207137
DOI: 10.1016/j.bmcl.2010.02.025
Patent ID: ┄