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ID: ALA1156556
Journal: Bioorg Med Chem Lett
Title: Knowledge-based design of 7-azaindoles as selective B-Raf inhibitors.
Authors: Tang J, Hamajima T, Nakano M, Sato H, Dickerson SH, Lackey KE.
Abstract: The synthesis of a 7-azaindole series of novel, potent B-Raf kinase inhibitors using knowledge-based design was carried out. Compound 6h exhibits not only excellent potency in both the enzyme assay (IC(50)=2.5 nM) and the cellular assay (IC(50)=63 nM), but also has an outstanding selectivity profile against other kinases.
CiteXplore: 18662874