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ID: ALA1156556

Journal: Bioorg Med Chem Lett

Title: Knowledge-based design of 7-azaindoles as selective B-Raf inhibitors.

Authors: Tang J, Hamajima T, Nakano M, Sato H, Dickerson SH, Lackey KE.

Abstract: The synthesis of a 7-azaindole series of novel, potent B-Raf kinase inhibitors using knowledge-based design was carried out. Compound 6h exhibits not only excellent potency in both the enzyme assay (IC(50)=2.5 nM) and the cellular assay (IC(50)=63 nM), but also has an outstanding selectivity profile against other kinases.

CiteXplore: 18662874

DOI: 10.1016/j.bmcl.2008.07.019