Document Report Card

ID: ALA1156576

Journal: J Med Chem

Title: Determination of log D via automated microfluidic liquid-liquid extraction.

Authors: Alimuddin M, Grant D, Bulloch D, Lee N, Peacock M, Dahl R.

Abstract: A method for log D (pH 7.4) measurement was developed using microfluidic liquid-liquid extraction. Values were determined for 26 compounds and compared to results obtained via shake-flask methods. Excellent correlation between the values obtained via both methods was achieved (R(2) = 0.994). The developed methodology is amenable to automation, enabling high-throughput determination of large compound collections.

CiteXplore: 18666772

DOI: 10.1021/jm8005228