Document Report Card
Basic Information
ID: ALA1156595
Journal: Bioorg Med Chem
Title: Studies on the antifungal properties of N-thiolated beta-lactams.
Authors: O'Driscoll M, Greenhalgh K, Young A, Turos E, Dickey S, Lim DV.
Abstract: N-thiolated beta-lactams had previously been shown to have antibacterial activity against a narrow selection of pathogenic bacteria including Staphylococcus aureus and Bacillus anthracis, as well as apoptotic-inducing activity in a variety of human cancer cell lines. We now have found that these lactams also possess antifungal activity against Candida and other fungi by exerting powerful cytostatic effects that disrupt the structural integrity of cytoplasmic membranes. The mode of action and structure-activity trends of these lactams as antifungals parallel that previously seen in our antibacterial studies.
CiteXplore: 18672374