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ID: ALA1156693
Journal: Eur J Med Chem
Title: Novel N-(phosphonomethyl) glycine derivatives: Design, characterization and biological activity.
Authors: Naydenova ED, Todorov PT, Topashka-Ancheva MN, Momekov GTs, Yordanova TZ, Konstantinov SM, Troev KD.
Abstract: A series of Calpha,alpha-disubstituted cyclic derivatives of N-(phosphonomethyl) glycine have been synthesized and characterized. They exhibited moderate clastogenicity, low antiproliferative activity on mice bone marrow cells and well expressed cytotoxicity against human tumor cell lines. The 8- and 12-membered cyclic analogs proved superior to the remaining compounds and were found to trigger apoptotic cell death in DOHH-2 cells. The latter compound caused 50% inhibition of the viability of hemobastose-derived cell lines at concentrations ranging from 20 to 67 microM.
CiteXplore: 17950497